Jesse Fuller, the great one man band of the Bay Area, wrote and recorded San Francisco Bay Blues in the 1950s, playing 12-string guitar, harmonica, bass drum, high-hat cymbal, "fotdella," and kazoo. Peter, Paul, and Mary famously covered it in 1965, keeping only the kazoo in their live appearances (but not on the record). Fuller's "fotdella" was a six-string bass of his own devising, played with foot pedals.
It takes all four of these guys to match Fuller's instrumentation: string, reed, percussion, bass:
Many different arrangements:
"The New San Francisco Bay Blues"
And, of course, there is Eric Clapton's version, from his Unplugged album — https://www.youtube.com/watch?v=l8zoUpfnFFE
EC can't be mentioned here. He expressed the wrong view on the "vaccine" (which he dutifully accepted).
The tolerant among us protect us from the intolerance of the enemy (EC) by censorship of his music, as listening to that music might hurt us.